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Kaposi-Sarkom

Definition

A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumours have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.

Synonyme

Kaposi-Sarkom, Sarkoma idiopathicum multiplex haemorrhagicum Kaposi, Morbus Kaposi, Idiopathisches multiples Pigmentsarkom Kaposi, Angiomatosis Kaposi, Teleangiektatisches Pseudosarkom, Angioretikulomatose

UMLS

SARKOM, KAPOSI-